are you hunting over bait or spot and stalk.
If shootin over bait, havier is better at 20-30 yards typical. I used 280Gr hardcast last year with 85gr of BH209, about equivalent to a 454 casul.
Spot and stalk, I would go with the Hornady FPB, Thors or any 300GR sabot load with a good jacket. Any of those will work well. Keep shots off the shoulder.