The best way to get rid of leading is to get a properly fitting bullet. One that is .001-.002 over your bore, and either size to fit for your cylinder throat or .0005 over cylinder throat. This will get rid of most of your leading. (Assuming your barrel is in good condition, ect.)
My 44 has a pretty big bore and cylinder throats, if I shoot .430 bullets through it, it leads like crazy and accuracy is pretty sporadic. If I shoot .432 bullets, leading goes away and the groups tighten up a ton.
The other thing is that really hard bullets tend to take a lot of pressure to properly obturate the bullet to prevent gas cutting. In this case either a softer bullet or a hotter load could work. If you push it to fast it will lead because of other failures.
The first thing I'd try is slugging your bore and throats, to see if you're using the properly sized bullet. If you are, try a softer bullet.
As far as gas checks, I've been told when you hit 1400-1600 FPS you should start gas checking the bullets.