Dand-
Big animal = Tough bullet. A TSX, Nosler PT, A-Frame, Fail Safe, all will work fine. No reason to over think it. Since you have a supply of the 200 grain TSX, I would load some up with the bullet seated to take advantage of your long throat, provided they feed properly from your magazine. Pick 3 or 4 loads out of a reliable loading manual, concentrating on upper level loads for good velocity. See what groups best in your rifle, and that's your load. No Bison is going to know the difference between a 100 fps faster A-Frame bullet and a slightly slower TSX. 1/2 inch groups are nice, but for the game and distances you will be shooting, anything under 2 inch groups will get the job done.
Larry