I agree, the 250 will be fine for punching paper, but even top loads will not equal the bushmasters velocities. Therefore its safe to assume that reliable expansion will not be achieved.
This bullet is one of the biggest reasons I opted to ream my 45 colt to 454. I have loaded the grand old colt to top velocities for years. But I also have a number of fine old colts that would be a down right shame if one of those loads found it under their hammers....
I rolled cannelures into the 250's and loaded them up in the Cassull to velocities on the heels of the Bushmaster. They shoot very well and will expand in game.
BTW, the 225g is made for the long colt and will expand reliably. BUT this bullet could be a problem the other extreme, its likely it will be too fragile at Ruger lever Colt loads.
Good luck,
CW