What Alacharger said: "If you use real BP, be sure to use an appropriately lubed bullet. ... Real BP needs a lube like SPG, or one made of beeswax and vegetable shortening."
When shooting black powder, never use projectiles that have been lubed for smokeless loads. I did once, in a small break open pocket revolver. Fouling builds into a HARD, caked on mess. After a cylinder or two of black powder .38 S&W rounds, the last projectile got stuck in the bore. No harm done to the gun, but it was a real chore, once home, to knock the bullet out without damaging the bore.
Shot .45 Colt black powder loads in my Ruger Bisley Vaquero without a hitch. I say "Go for it."
Cleburne