If you want to use "Bullet Energy" as a criteria, (an in-accurate criteria, I believe), then using the above noted Hornady ballistics, either slug load will hit a deer with as much, or more energy then a .44 magnum handgun, held point blank up against a deers ribs. So, as others have said, the real issue is knowing your range, and being able to place those slugs consistently in the kill zone.
Larry