...just blow through it and see....if it is a little flat...take another 1/4 inch off and try it again......
Sorry...just kidding....I am sure there is something to what you are saying, I certainly wouldnt go cutting holes in MY barrel. I think a muzzle break has to be done very precisely, it would certainly effect accuracy if the ports are uneven, I dont think you would see much difference as far as the front sight is concerned. However....I have a few long barrels that somebody installed a 'rear' sight in the middle of the barrel, I sure wish that they werent there. I think that would affect 'harmonics' a lot more..
I'm certainly not an expert though.