Hi 44 Man,
It's sort of neat how closely we dovetail: I have the fixed sight .44 Bulldog for carry, and my favorite load is almost a duplicate of yours, the 240g Keith semi-wadcutter, though I use only 7.0g Unique. This combo shoots dead on for me, making great practice. On a couple of ocassions, I've put all five in a paper plate from 50 yards, and when I don't, it's sure not the gun or ammo.
For carry, I also use the the Silvertips, but the POI shift isn't significant to me: I can see it being annoying if your target is a string or a Necco waffer, but if it's a big burley chest at ten or twenty feet, it's no biggie to me: you don't get extra points if your slug is dead center in the X-ring, or it's half an inch away: It's same-same: equal value, either way.
I also have a .22 Target Bulldog with adjustable sights. Really sweet, though I don't shoot it as much (prefer the Redhawk).
Regards,
kbmoly