Couldn't they withstand smokeless powder charges?Of course they could stand some kind of smokeless charge but the question is how much of what? Slow burning propellants like H870 require a lot of pressure to burn efficiently and there is much less inertia in a cannon shot due to the spherical shape than there is in a typically shaped rifle bullet.
Since smokeless is something like three times as powerful for the same volume, you would have a problem with the charge being so small that handling and ignition would be problems.
Another major problem would be the tendency of smokeless powders to burn faster as the pressure increases which leads to KABOOMs. Thus the general rule to use only black powder or tested substitutes in muzzle loading guns of all types.
If you have pressure testing instrumentation, you could develop smokeless loads for muzzle loading artillery but without pressure measurements, you are really swimming in unknown waters.
Besides, if you want to play with really high performance cannon, join the Army.
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