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The .22/250 and .308 Winchester case have the same case head size, no change is necessary to the bolt face or extractor if the new round is a .308 Winchester. You did not state however which .308 case you will be changing to. If it is a belted magnum .308 then the bolt face will need to be opened up and the extractor modified. And the .22/250 length action may not be long enough for the round.