I have shot cast bullets from Marlin Microgroove barrels in the following calibers: 30-30, 35 Remington, and 45-70. I've loaded cast bullets for these rifles since I started casting in 1974. I've only got one 45-70 Marlin, but have had several different rifles in the other two calibers. All have been Microgroove, and I've never had any accuracy problems with my cast bullet loads. In my 35 Remington, I find the RCBS 200 grain flatnose cast bullet to be slightly more accurate than jacketed bullets. If you handload, and are careful with your loading procedures, you should have no problem at all. Before you begin loading though, slug your bore to find the proper diameter cast bullet you'll need. I'm not much of a handgun shooter, and my pistol caliber leverguns have Ballard rifling, so I haven't encountered the situation that Sidewinder has. That having been said, though--every gun is different. What is an optimal cast bullet for your rifle may not be optimal for your handgun of the same caliber, microgroove or not. I cast my own bullets, and do not rely on storebought cast bullets in any of my rifles. I certainly wouldn't pass up a bargain if I found a Microgroove Marlin in a caliber that I wanted, in good shape.