Personal choice will drive replies I'm sure as it drives mine.
My choice is an easy one - the easy open Contender frames made from 1981-1999, approximately starting with serial 195,000 for the blue, or any of the Contender stainless frames made from 1993-1999. The Armor Alloy frames/barrels never tickled my toes, so I didn't keep mine long. The easy open Contenders have great triggers, and can be taken to 6 ounces or less safely. Jim Henry (Barstow, CA) is THE Contender smith, and will completely tune a frame and trigger to target quality for a very small cost (last one he did for me was $20). Contrary to the selling points some folks will tell you about G2's, the G2 IS NOT any stronger than the Contender, and the Contender CAN BE re-cocked without opening the action. Of the 45ish Contender frames I've owned since 1968, about 80% of them were easy open. I've owned zero G2's, a choice I made after handling the prototype under the table at the 2000 SHOT Show that never changed.
As for barrels, every frame is unto it own. Some will readily accept any vintage Contender barrel made from 1967 on - some will with a little stoning of the barrel bolt - some will require changing the barrel bolt. TC will still supply the parts no charge as far as I know, and they only take you a minute to change out with simple tools.
With upwards of 250 cartridge choices for the Contender (including the wildcats), it will do anything you'd ever need for target or hunting, but with 1 pound less weight than an Encore.
HTH-YMMV