My sons shoot deer, lope elk and black bears with there 257AI, I first start loading it with 115npt for deer, there where so impressed with the DRT that when I wanted to try 100gr npt they said no, when they went elk hunting I wanted to go to the 120npt and they said no, 1 shot kills on them and did not go more then 20 yards, when they took them black bear hunting in the fall, and with all that fat it can plug a wound and not leave much of a blood trail I again wanted to go to the 120's, and again they said "dad, dont mess with success" the bears went less then 50yds. We only put 1 into them to see how far they would go since I could keep them in sight of my 45-70. I just bought a 257Wm, and will use the 115npt and try the Hornady 117 Interlocks and see how they group. I am sure the 100gr npt for deer and lope would be fine.