I've had no problems with feeding 185 to 200gr LSWC in Ruger and Kimber .45s, certainly worth trying. I've needed to tweak seating depth/OAL on a couple of loads to prevent the occasional misfeed, so don't give up if it doesn't feed 100% reliably at first. In my experience, I've needed to go a bit longer when that happens.
Also, I've not seen any leading issues, so long as the bullet isn't undersize for your bore.
For a target load, I'd try something like a 200gr LSWC over 3.5 to 4.0 grains of Bullseye - I've heard this called the "Classic .45ACP target load" or the "NRA .45ACP target load". My Ruger likes them a tad lighter and warmer, I get better accuracy and consistency with 185gr LSWC over something close to 6.0gr Bullseye.
As with any firearm, yours will prefer its own load that may be very different than mine, and always, Always, ALWAYS check loads against multiple published sources before using them.
Just a Shooter