Well, I will go first.
22/250 uses Large Rifle Primers.
.
Started by drilling the flash hole to 11/64", put the brass in a sizing die to hold it.
3/16" would have been better but I probably broke that one trying to open a can of a paint or something.
Neck sized and hand primed with Win WLR primers.
Tried seating the pellet with with dies and then Lee Loader, but the pellel falls in the bras and it goes in the trash.
Finally just wiggled the pellet in with my fingers to hold only the bottom cup part.
Using Crosman pellets.
.
Results - out of 7; one did not make it out of the brass.
6 shot into a 3/4" group at 15 yards about 2.5" low. With a 1.5" scope ht, that means its not rising at all.
FWIW - shooting a paper target stapled to a cardboard box filled with phone books.
pellets broke the paper but not the cardboard, bounced off, onto the floor.
.
Next step is to try magnum primers, before I go drill for 209's.