Personally I would avoid any contact with ground squirrels anywhere in the Western US. Clearly they are good to eat, since every natural predator smaller than a mountain lion eats them (and grizzlys dig them out of hibernation just before the griz goes to bed for the winter, too).
BUT (the big butt), there are a few cases of bubonic/sylvatic/pneumonic plague (the "Black/Red/Just Plain Death") in the West each year, and they all come from handling ground squirrels. Since the disease is usually not diagnosed until too late (usual early symptoms like flu), they are commonly fatal.
For more info on this grisly subject, google "ground squirrel diseases." Just sayin'!
Great targets, tho, and the cattle industry HATES them, as do all horse raisers.