Hi,
What Pedersoli have you in mind? I have a Pedersoli Sharps Silhouette in 45-70 which I shoot with nitro. I buy off the shelf 405gr PMC for target shooting upto 200yds. Accuracy is good; shooting prone I can group most of my shots within a 4" bull. The rifle is certainly capable of much better performance with handloads and that's upto you to test and choose.
For the price and availability, you can't go wrong with a Pedersoli Sharps. They are good rifles.
Kris