Sorry I can't reply with experience on the 180's. All of my experience is with the 150's, which is all I think anyone needs in the .30-06 for deer. Every animal I have shot (exotic deer and hogs) with the .30-06 was the 150 grain Remington factory load Core-Lokt. All of them went down where they were hit and didn't get up. My aim is vertical cross hair in line with the front leg and horizontal cross hair about 1/3 of the way up from the bottom of stomach/chest. If I don't have that shot, I don't take it.
I couldn't ask for anything more than that bullet has done for me. I recently sold my .30-06 and will switch to using my .308. I will start using that same Remington 150 grain Core-lokt for my .308 and not question what it can do on deer sized game out to further than I can shoot.
By the way, the Remington Core-lokt is my favorite (deer/hog) bullet...in case anyone didn't catch that in my writing above.
Good Luck!!