In my 5 1/2" 97, I run 17 gr. of 2400 pushing a 250 XTP with CCI 350's for a bit less than 1200 fps. This is as low as I personally want to go on velocity, although some others will disagree.
In my full size Ruger Blackhawks (and Redhawks when I owned 2), I have run 19.5 gr. 2400 with the 250 XTP and CCI 350's for years. I don't have that info handy here, but I think I remember the velocity being around 1300 fps, depending upon barrel length.
Although 1300 fps always makes me a bit happier than 1200 fps, either will handle stuff from jackrabbits through deer and hogs adequately, in my experience. I've not used that bullet on anything larger, preferring the 300 gr. Sierra or 300 XTP, either in regular or Magnum version depending upon the game.
I've had no need or desire to use any 300's in my 97.