Being a cast bullet fan, a quality cast bullet with a wide flat nose (meplat) in a weight of 250 or more grains is simply a very good way to go.
Crusty Deary Ol'Coot
I agree You can't beat a good heavy cast bullet for the .44 mag. with a large meplat bullet. Its where the .44 shines.
Here's an article by Randy Garrett who specializes in making ammo for the .44 and 45/70 for taking large game.
Where defense against bear attack is concerned, the best bullets for the large caliber handgun are clearly proper hard-cast bullets. Expanding bullets are far too likely to fracture when impacted into the tough bone of a bear’s skull. This should be rather obvious as any bullet designed to expand against the light resistance of a deer’s rib cage cannot be depended upon for major bone busting on a big bear. When selecting a hard-cast bullet for such applications, one should be careful to choose an extremely heavy bullet with a broad frontal flat (meplat). It is also important that the casting possess substantial inherent strength, with a hardness rating of at least 19-Brinnell. The importance of selecting a heavy bullet is twofold. First, heavier bullets penetrate deeper than lighter bullets. Second, since heavier bullets cannot be driven as fast as lighter bullets, they experience less impact stress and are therefore less likely to fracture upon impact. This is very important, as the amount of stress experienced by a bullet upon impact is the result of the speed of impact and the toughness of the target. When the target is close and extremely tough, reliable performance is always best achieved by increasing bullet weight and decreasing velocity. The importance of selecting a bullet with a broad meplat is also critical, as broad meplated bullets tend to penetrate deeper than small meplated bullets. It has become obvious to me through the years that although logic would seem to suggest that heavy bullets with small meplats should penetrate deeper than blunter bullets of the same weight and velocity, they usually don’t. This is quite interesting, as it would seem that the bullet with the smaller meplat would offer less resistance to penetration and therefore should penetrate better than the blunter bullet. However, nearly three decades of penetration testing with the 44 Magnum has established beyond any doubt that the blunter designs penetrate the best. The truncated cone is an excellent example of this. Although possessing meplats in the .210-inch to .230-inch range, truncated cones do not penetrate as deeply as semi-wadcutters of the same weight and impact velocity, and yet the semi-wadcutters I have tested possess meplat diameters of about .285-inch. Later testing revealed that penetration would continue to increase as the meplats increased in diameter up to about .320-inch. However, my penetration testing demonstrated that meplat diameters significantly greater than .320-inch, in 44 caliber, did not increase penetration depth, but instead led to decreased penetration depth. It is always easier to observe than explain, however it is my opinion that the reason for this pertains to the disparity in weight distribution of small meplated bullets. Simply stated, when the back half of the bullet carries significantly more weight than the front half, the back half tends to over-take the front half upon impact. In other words, the bullet tends to go sideways since the back half carries more weight and has more inertia. As the weight disparity between the two ends of the bullet is reduced, as in blunter designs, there is clearly less of a tendency for the back half to over-take the front half, and the bullet takes a straighter and deeper path. However, once this weight disparity has been corrected, any further increases in meplat diameter tend to decrease penetration depth as terminal stability can no longer be improved.
