I had a C. Sharps 45/120. I tried to find an accurate load. After many many attempts, I decided I was using the wrong primer. Having already primed those expensive cases, I decided to un-prime them so I could put in the new primer.
Keep in mind this was several years ago when I was more of an idiot than I am now. I had no bench mounted reloading press. I used a skinny punch and a little hammer. Insert the punch into the case and tap out the primer. I held the cartridge in my left hand, making sure no part of that hand was at the bottom of the case. I un-primed numerous cases one evening, no detonations. Started to get careless about left hand position. One went off. I looked at the heel of my hand and it was bleeding. Ouch. Kept working. Over the next few days, the wound healed over, but kept hurting. Went to the doctor, got my hand xrayed. He showed me the film. There was my primer. He sent me to a surgeon. Surgeon took one look at the xray and said he could get it out, but the risk of permanent nerve damage was too high. Today, I have a bulge there, a great reminder to treat every cartridge with great care and think about what you're doing.
I never did find a suitable load for that 45/120. The most I could get out of it was about equal to a black powder 45/70.