I spent a decade one weekend...........
Biggest 'yote Ive ever seen here looked to be almost the size of a small female wolf, and may have actually been one; it was a quick view and 3 jumps gone. Ive never been a snap shooter so it would have been no shot for me, but it was only about 30yd.s, so no need for a 'surgical' .223 or 22-250. As an all rounder I like the idea of a 25-06, though. Your local ground and conditions will probably be the determining factor, and where/when you tend to see 'em, unless, as said, you can call. Im usually moving and doing things, so whatever Im carrying would be the tool of the day (thus the 'dance with who ya brung').