I've heard on average the pressure is only increased if you had went up a grain? Or something like that. Probly more or less depending on the powder. Even if there's no increase in pressure with a load it could be a whole different ballpark in grouping though, so even then it's still better to work back up
I used to just use them in my 7mag, but here lately i've been starting to prefer them in larger cases like the 30-06 and 45-70. I get alot more reliable ignition with some loads