The 'new' frame is the same size as the original BH frame, which got upsized after a while and the same as the original Colt's Mdl P. IIRC it really is only an issue if you want to make hot handloads in 45Colt, in which case there is not a lot of metal left in the cylinder walls after reaminig the chambers. The 44s are better in this regard and the 357 no issue. All are rated safe with factory loads (FWIW, manufacturers dont accept handloads anyway) and factory top loads are more than I want to shoot for fun, so I use low to midrange handloads. If you have very large hands and just like a heavy handgun, the early Vaq. may suit you better. If like me, 6'1" with longish fingers and for sure a 'large glove size' the new models feel great and dont pull my pant down quite as bad as the bigger models when in a belt holster. I do much prefer a shoulder rig and the shorter barrel 4 5/8", or even less maybe someday (on my wish list).