For moose, the area just below the Hump works well (spine, lungs, heart). There are no normal calibers that will absolutely guarantee a busted shoulder, and I don't go there. I have used neck shots on other animals, but generally, it's not my first choice.
Butt shots, in my opinion, on moose (and other animals as well) are a NO GO. No caliber normally used can penetrate that far reliably, that includes most, probably all, of the magnums. Sure, it can be done, but chances are real good it won't work. Only way I'd try it, is if I was chasing down wounded game.