The 40 S&W is not inherently dangerous to reload. It is a high intensity round, and like any such, needs to be loaded properly. That means sticking to book loads, ensuring proper bullet seating depth, etc.
Most all problems with any reloaded ammo usually come about when powder charges are not checked properly (double loads with fast burning powder happen), bullets are seated too deep, causing pressure spikes, or are not crimped properly, allowing them to be pushed back in the case during feeding, or from recoil. Using the wrong primer, or a bullet the same weight as a book load, but of different construction / bearing surface can also increase pressure in a small, high pressure case.
Problem with a gun with an un-supported chamber is that it can cause a slight bulge in the case webb. If you reload these cases, the working of the brass by the resizing die can weaken them in this area, causing eventual failure. Not very often, but under the right circumstances (work hardened brass, stiff loads, maximum spec chamber) it does.
Larry