The key to accuracy in rifles is to eliminate or reduce bullet deformation. When a round is fired, the bullet jumps from the case and starts into the rifled bore. If the bullet enters the bore perfect, the only deformation will be from the rifling. This is the optimum condition. Unfortunately, most chambers aren't cut perfect and most bullets aren't seated perfectly, so some deformation occurs. A deformed bullet will exit the barrel and be slightly out of balance. This causes a "whiffle ball" effect and will open up the groups.
To minimize bullet jump deformation, there are a few hand loading steps that will really make a difference in your group size.
Most handloaders trim their cases to SAAMI specs listed in reloading manuals. This usually results in a loss of accuracy. Almost all rifles have a deeper free bore than SAAMI minimum (trim length) so when you trim your cases, it leaves a void between the case mouth and the rifled bore. This empty free bore area is more than .025" larger than the bullet diameter (measure the neck on a spent case and compare it to the bullet diameter). When the bullet is forced under high pressure, it has an opportunity to move sideways a little and enter the bore slightly off center. The bullet will be deformed and will loose accuracy down range. The fix is to let your brass "grow" to fill as much of the chamber as possible. The perfect brass length would be .005 short of bottoming out, leaving a little room to grow without corrupting the chamber.
The next task is to find a way for the bullet to exit the brass straight. If you inspect your cases, particularly the neck, you'll see most brass cases have thick or thin areas and non-squared case mouths that cause the bullet to be released slightly off center. To get a nice squared case mouth, you can trim a tiny bit of metal from the mouth until you see fresh cuts around the circumference. Neck turning will true up the neck but is a pain to do. I anneal my cases from the shoulder to mouth and get the same effect. A soft neck will release the bullet before pressure is maximum and will start the bullet straight into the bore, even if the neck isnt perfect.
The last task is to seat the bullet at the optimum depth. After years of testing, Ive found when the ogive is .010 off the lands, bullet jump damage is minimized and accuracy will be at its best. I use a bullet seating tool to measure for optimum seating depth with the actual bullet I will be using in my loads. As mentioned before, all bullet styles, even in the same weight, will have a different ogive dimension. Some rifles have such a deep free bore that bullets want to be seated out too far for the cartridge to fit in the magazine. You can either single load, or find a bullet with the ogive farther forward.
Since I invented and started manufacturing the chamber tools referred to in my above post, I have used this 3-step approach (case length, annealing, and bullet seating depth) to make 3-4 MOA guns into sub-MOA shooters. I have also taken guns that fired decent groups and made one holers out of them. Assuming quality bullets, proper powder charge and a sound gun, (no eroded or off center chamber, bad bore, or non-symmetrical crown) this technique works very well.