My 22C was my first pistol, and it is still my favorite. Great all-around, but if you want something for CCW, you may want to look at the 23 or 27, especialy since the larger mags fit no problem, and grip extensions are available to give them a better grip in the 27's case.
Only problem with mine happened a few years back: the pin that holds spring tension on the slide lock broke and fell out, and the slide would lock back after every shot- the recoil made the slide lock jump enough to catch. I could still shoot it semi-auto if I held the slide lock down with my thumb. I'm sure this is not a common problem.