With .45acp, generaly the heavier and slower the load, the higher it will shoot at short range-25-50 yards.
Since you are new, I have to ask the obligatory question. Is it possible you are anticipating the shot? Most new shooters will push the pistol down in anticipation of the shot. If you are covering the bull with the three dots and shooting heavy slow ammo (Blazer 230), the last thing your shots should be is low. Lighter, faster loads will only shoot lower.
What kind of groups are you getting?
The HK will handle any load, exept bare lead, you want to put down the pipe.
One way to tell if you are anticipating the shot is to have a freind mix in some snap caps in your mags, and when it goes click instead of bang, you'll know.
The USP .45 is one of the finest .45's out there. More practice, more experience, better groups.