kkeetr,
I've shot several deer, at least one bear and a few caribou with the Speer 145 HotCores in my 280 rem.. In my opinion, the bullet is too soft for anything but side shots on deer sized animials. Maybe a 7x57 or 08 will slow it down enough to make it a better bullet, but i doupt it!!
I've shot numerous animials with Speer hotcores, and Hornandy innerlocs ect.., and those are the very bullets that made me switch to Nosler partitions!! I like my bullets to stay together better than the Speers, Hornandys and other non premium bullets do. But then again, i've hunted most of my life where there are bigger animials too.
Drilling Man