Sounds like the same old - same old. I see two(2) barrels listed, and both have the same problem, and both are firing handloads. My .02 cents, T/C is notorious for having weak firing springs after use. Knowing this, How old is the frame, or how many rounds has it seen? Second, How deep are you setting the primers? I have a .35 Rem barrel that is very tempermental when it comes to primer depth. I actually put a stop on my hand primer so i wouldn't seat too deep. This is the only barrel I have this problem with, so I know it's not a spring problem. Had to replace springs in both frames I own due to the same problem you're having. Problems stopped in both guns right after fixes!