JS44,
I keep about five pounds of powder around at my house; 2 2f, 2 3f, and 1 4f. I figure that if there is a fire in my garage and the powder goes, it's only going to do in a burning garage anyway And it will have to burn through my home-made sand filled box inna box to get that far. For the 30-06 try a 165 grain bullet with 48 grains of IMR 4064, or 180 grain bullet with 55 grains of IMR 4350.
I am not a pusher of black powder substitutes, but I can see where in some cases it does help. One thing that I have done before is to load a duplex load. I put down 5 grains of 3f, and then the rest of the load either in Pyrodex Rifle or pistol powder. The five grains of 3f easily ignites the pyrodex. I have also used this duplex load in flinters.
C F