Bottom line you need to be a seasoned handgunner to be shooting 100 yards using a wheelgun or just a gifted natural shooter, a good rest and maybe a shooting stick and a really good squeeze LOL. Using open sights I would think thats a bit too far but can be done and has, using some type of optics will increase your chances for a good site picture and a clean shot, Scope/redot ect... many days at the range will tell you if you can be steady enough to be accurate at 100 yards...If you can get some good grouping at 100 yards, I would not hesitate a good clear 100 yard shot using the right load and bullet for the game you are hunting. I limit my self to fifty yard shot while still stalking and 100 yards at a stand using a shooting stick, we all have to know our limitations, if you can't do it at the range, don't try in the field, might end up wounding a animal needlessly. Aim small hit small. RAMbo.