I hunt big game with rifles, and recently have started using handguns. For right now, the only big game that I have hunted is whitetail deer and hogs.
On whitetails, I place the cross-hairs either half-way down right behind the shoulder, or in the middle of the neck. The neck shots drop the animals in their tracks. The behind-the-shoulder shots cause them to run up to about 100 yards and then they drop.
Where do you place your shots?
Zachary