This is a subject dear to my heart. I have been a dedicated handgun hunter for more than thirty years. I have been fortunate enough to kill deer with many calibers (357,41,44mag, 45colt,10mm,454 casull,480 Ruger,& 500 Smith. Any of these will do the job if you place your bullet where you should. I have only used the 357 a couple of times. Felt that it was marginal. I really love my Smith 500. I admit its not for everyone. Not as unpleasant to shoot as some say. Main thing is "do it right" know your limitations. Have fun & good luck.