The main purposes of designing the OWC was to make it possible to obtain accuracy at longer ranges than with full wadcutters. It is accurate out to about 100 yards when driven at normal WC speeds, so it give more dramatic results on pests and varmints with mild loads out to the range limit for most shooters with their sights on small targets.
Use the WFN whenever you want power, super killing performance on large animals, and long range performance. The LFN will range out farther and kill very well with full loads.
In 45 caliber, which you are interested in, the WFN in 280 to 325 grain weight, loafing along at 1200 fps, will drop most large game in their tracks with chest hits, and the loads will be pleasant to shoot, especially with the lighter weights. Of coarse if it will drop a moose it will probably do at least as well for a mouse!!