I killed one 45" moose with my Contender in .35 Remington. This was over 15 years ago, and I used the 250 Speer SP; the 220 was not in production at that time. The shot was at 25 yards as he trotted quartering towards me. Broke the front leg as he landed on it so down he went, and stayed down. After breaking the leg the bullet went through the lungs and lodged in the off cavity wall. There was little expansion, as one would expect with this tough bullet. I finished him with a .45LC bullet in the neck.
Today I'd use the Speer 220 or the Nosler 225 BTip, loaded as fast as I could safely push it. But don't expect him to die immediately.