What amunition will you be using? What sights, iron or scope? What is your skill level?
A 300-grain bullet launched at 1600 fps will kill a deer well past 150 yards - done it, the Hornady bullet penetrated from stem to stern, expanded to 150% diameter, and lodged under the hide at the rump. But bullet drop will be a determining factor too. Sighted in at 100 yards means the bullet hits 24" low at 200 - you'll miss the shot, trust me. Sighted in 1.5" high at 100 yards the bullet still drops 19" at 200 yards. Sight in 1.5" high at 100, you'll never know the difference between that and dead on at 100 yards in the field, and the bullet will land a bit higher at longer range. I'd not shoot past 125 yards any more - too easy to misjudge and actually be shooting at 150+. That would probably mean a miss or a low, leg-breaking non-fatal shot. All thia assumes you can keep all your shots in a 6" circle at you shooting range in the field.
