The Optimal Charge Weight (OCW) and ladder (AKA Audette ladder) methods will only help you find the best powder charge for a given type of powder with the components you're using. Although you can get a good idea of the performance of a given rifle and load, these methods do not necessarily tell you which bullets, powder, primer, etc will be most accurate, you may still have to use group tests to determine that.
I'll post a couple links below where you can read more, but here's the overall idea...
The OCW and ladder methods rely on the Optimum Barrel Time (OBT) or "Shock Wave" theory. This "Shock Wave" theory says that when a round is fired, a shock wave begins at the chamber, travels to the muzzle, then back to the chamber, back to the muzzle and so forth. If the bullet exits when the shock wave is near the muzzle, the load probably won't produce good accuracy, and if it does, it will be extremely finicky and any slight change will cause a loss of accuracy. What is preferred is to have the bullet exit when the muzzle is most stable and the shock wave is back near the chamber. The OCW and ladder methods basically show you where your powder charge needs to be for a given load to have the bullet exiting at the best time. What you're looking for is a place where incremental powder charges tend to cluster together. This gives you a load that is consistent from day to day and slight variations in components or enviromental conditions don't affect the load as much as it otherwise would.
I believe just about everyone has had a load that would shoot amazing one day, but then if the conditions changed even slightly, the groups opened up quite a bit. The OCW and ladder methods are aimed at reducing or eliminating this inconsistency. However, an OCW load doesn't always produce the smallest groups possible (they're usually very good though), but it will give you a load that will shoot consistenly in a variety of conditions. I'm not a BR shooter who is constantly tuning my load for varying conditions, so I prefer the OCW method to help find a load that will perform well throughout the year in a variety of conditions.
There is somewhere on the net that describes the ladder method, but I don't have the addy. You can probably find it if you do a web search for "Audette ladder."
You can read more about the OCW method at
http://www.clik.to/optimalchargeweightYou can find the OBT theory at
http://www.speakeasy.org/~cdlong/shock%20wave%20theory%20summary%20explanation.htm