Are you hunting over hounds or bait?
I think for a spot and stalk hunt, the 4" Smith would be a disadvantage. Don't get me wrong, it can be done. I have shot a couple of real nice big game animals with short barrelled revolvers. However, most of them have been targets of opportunity. By that I mean, when glassing, I find the animal that I want to kill in a position that provides enough foliage, break in terrain and etc to get close and then I'll decide to take it with the shorty.
I have shot several bears, a number of antelope and other animals with a shorty... you just have to be selective with your stalks.