At the range today I fired two separate rounds thru my 3 3/4", 45 Colt Vaquero. The first was 14.5 gr. of 2400 (under a 240 gr. LSWC) and at first it looked like it was going to be the cat's meow, but by the time the box was empty the groups were all over the place. The next box was 15.5 gr. of the same dust and at 25 yards I kept eleven out of twelve inside a 5 1/2" bullseye (shooting Weaver stance). I'll experiment with a warmer load and see if the groups shrink more, but right now I'm feeling pretty good about that gun/load combination.