what's a Rexio? I've never done much hunting with a 410 but it should suffice for squirrel. There ar couple of guys here that have done quite a bit of hunting with them maybe they'll chime in. I have'nt heard much good about the usefulness of the barrel for shooting .45s either. The bead sight and distance the bullet has to jump to contact the rifling make it not so accurate from all of the reports I've read. I'd prefer a 20ga for the bushy tails, probably because that's what I've always used.