A couple of years ago I shot a little blacktail spork (spike by fork) with the 44-250 Nosler Partition Handgun. It was about a 60-70 yard shot offhand. I hit him even with the backside of the front shoulder right on the underside of the spine. Broke a rib on the way in, hit the bottom side of the spine then turned 45 degrees down and forward and left through the offside shoulder. I don't know why it took the hard turn when it hit the spine, but it did drop him right there.
It might have sheared off a petal and began to tumble, who knows? I did not recover the bullet but the little buck did not take a step.
I would certainly use this bullet again for deer but I would go to a heavy hard cast if I were going to hunt anything larger. (elk) It would be a much better bullet if they bumped it up to 300 gr by adding another 50gr to the rear (behind the partition) of the bullet.
Good luck, shoot well, shoot often, and have fun.
Joe