Mike - another caliber you could try for your wife is either a 260 or a 6.5 Swede. Remington still offers both, I believe. The 260/6.5 can be loaded up for Moose, Elk or Bear, yet loaded down fer vermits.
The Remington is, in my opinion, a much classier rifle, probably one that would definately suit your Mrs. better that some ol Ruger, seein' that she is a Lady classy enough to be your wife (those are statements that always help turn a gal's opinion more toward your way of thinkin'. And, the 260/6.5 Swede is most definately a classic (6.5) and classy cartridge. My opinion is that if a woman is savvy enough to argue for a 243 over a 38-55, she has to be classy enough to go for the Swede.
Now, as fer as the 'if momma ain't happy business': Just tell her that neighter the 243 or the Ruger are classy enough for her and that you're getting her something that is more in line with her grace, elegance, classy nature and hunting skills. Now, with that she might expect something silver inlaid in a diamond encrusted stock complete with collage of friends, family and hunting successes, or she just might like to have a beautiful wood stock. I think you have a lot of room to maneuver here Mike
Also, the Remington actions for the 243 and the 260 are the same size - both rounds are based on the 308 and are the same length. I think the same goes for the 6.5 Swede, so your wife would be shooting the same sized rifle, just in a better caliber fer whatcha want.
And, I do hope this helps. Mikey.