For Big Game (Caribou, Moose, and Bears) I like to use the Nosler 180 Partition. I got a nice Caribou last August, a 250 yard shot. He was running and I hit him a bit high, took out both lungs. I also got a Cow Moose in November, a 200 yard uphill shot. Hit her right between the eyes, she just dropped her head, never kicked.
But since I am in Grizzly country I like the ejectors on my Handis, helps in speedy reloading. Makes a difference when what you are shooting at can turn around and eat you.