Take both; I use my 300 Wby. mag. on the longer shots and 45 70 and 444 marlin for the close shots. If you're going after the 400 pds. and up,carry the 300 mag. I've been trying to nail one here in S.E. Okla. for the past month that will go well over 500 pds. If you've got the 243 in your hands and you get a shot at a big one,shoot for the neck because thats about the only safe way to drop him in his tracks. If you shoot one and he runs off into a thicket( he probably will) don't go in alone,get someone you trust to not run to go in with you. Digger