Looking at the Hodgdon data, I think H4895 or H380 would be better choices in the shorter barrels due to their faster burn rate, and pressures are lower for given velocities which is always good. Since I have both, I think I'll give em a try along with a box of 40gr Vmax that don't shoot good in my Hornet... :wink:
Tim
EDIT: Burning the midnight oil..... :roll:
Hmm, looking at the lyman 48th, IMR4064 looks like a good one too as it's their most accurate load and not too slow either, at a max of 3920fps for less than 50kcup....in a 24" barrel, too!! Since Handis seem to like less pressure, the powders that provide the best velocity with the least pressure have been the most accurate for me and I'm 100% so far with those I've picked for several calibers......Fred is right on again!! For comparison, Varget attains 110fps more but at a cost of more than 2kcup which might easily be too much more for a Handi..
For me, I can't see loading the 22-250 down to .223 levels to get the same accuracy, I prefer to achieve the velocities the caliber is capable of....no offense meant, Rick....