Fillers may be recommended with some load data for large capacity cases with low powder charges, but I haven't seen any powder mfr recommend fillers, in fact, the load data that I use from Hodgdon and Accurate Arms specifically state NOT to use fillers. Fillers keep the powder near the rear of the case in large cases like the 45-70, a lighter charge can put the powder entirely away from the primer flash hole and cause erratic ignition, accuracy and pressures. My recommendation is to used published data and if fillers are called for, by all means.
Tim