No first hand experience in handgun hunting, but, from what Ive seen on net and magazines, general consensus among experienced folks is: for wild boar and other larger game, a load in 44 or 45 caliber, bullet 300+ grains at 1100 fps min., 1200 fps preferred. Sure, higher velocity is better, however, killing power isnt going up considerably, but muzzle blast and recoil do. Next, take such load in handguns you prefer and see how you could handle them. Rugers, FA model 83, BFR, DW and Colt Anaconda should take this load without the problem, especially FA and Redhawks. S&W are nice guns and safe with those loads but prolonged use will make them loose. In that respect, Redhawks are the best, no screws to get loose, only single one on stocks. Talking about Redhawks; Super Redhawk is easier on hands with heavy load than standard Redhawk due the better grip design, and better grip selection to boot. But, barrel lengths from factory are 7.5 and 9.5 only.
If the weight and recoil handling (for many shooters) are the issue, good single actions rules. In that respect, Bisley 45 is the top. However, one important note; grip frame and ejector housings screws do get loose. Before going out, you have to make sure that all screws on any SA revolver are tight, better yet, apply something to prevent unscrewing.