I've been shooting crop damage deer (does) this fall with my 375 JDJ and am very pleased with how it drops them.
It goes: BOOM....WOP...FLOP!
I'm loading 53 grains of AA 5250 under the 220 gr. Hornady flat point. (Standard disclaimers. This is only 1 grain under the AA posted max load.)
Two longer range ones, 190 and 170 yards, didn't take a step after being hit in the front sholder.
Bloodshot isn't as bad as I thought it would be either. Just a quarter sized exit wound.